The Quiet Conversation Between the Gut and the Midlife Brain
Think of the gut as a long-term relationship partner that’s been quietly co-regulating your mood, immunity, and hormones for most of your life, mostly without you needing to think about it. For years, estrogen has been part of that relationship. Estrogen doesn’t just act on the ovaries or fat tissue. It shapes the gut environment itself. Certain gut bacteria actually respond to estrogen levels , and some bacteria help metabolise and recycle estrogen through what’s called the estrobolome . While estrogen is relatively stable, this system hums along quietly. Mood is more resilient. Inflammation is better controlled. The gut lining stays more robust. Then menopause arrives. As estrogen becomes erratic and then declines, the gut ecosystem feels that loss. The diversity of bacteria often decreases. The species that thrive on fibre and produce calming compounds don’t compete as well anymore, especially if the diet has been restricted over the years. At the same time, stress-respons...